9GIB

NMDA bound to compound 380

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyType 2 solute binding protein-like 8036603 3000083 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
PF10613Ligated ion channel L-glutamate- and glycine-binding site (Lig_chan-Glu_bd)Ligated ion channel L-glutamate- and glycine-binding siteThis region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF ...This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.
Domain
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
PF10613Ligated ion channel L-glutamate- and glycine-binding site (Lig_chan-Glu_bd)Ligated ion channel L-glutamate- and glycine-binding siteThis region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF ...This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Glutamate receptor
Isoform 1 of Glutamate receptor ionotropic, NMDA 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR018884Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomain
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR015683Ionotropic glutamate receptorFamily
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR049873Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domainDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR015683Ionotropic glutamate receptorFamily
IPR049872Glutamate [NMDA] receptor subunit 1-like, ligand-binding domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
Pharos:  Q05586