9JZ1 | pdb_00009jz1

Crystal structure of Nir2 C-terminal domain in complex with phosphate

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF24695	PITM 1-3, beta-sandwich domain (PITM1-3)	PITM 1-3, beta-sandwich domain	This is a presumed beta-sandwich domain found towards the C-terminal of Membrane-associated phosphatidylinositol transfer proteins 1-3 (PITM1-3) and RDGB from Drosophila. These are class II phosphatidylinositol transfer proteins (PITPs) which can tra ...	This is a presumed beta-sandwich domain found towards the C-terminal of Membrane-associated phosphatidylinositol transfer proteins 1-3 (PITM1-3) and RDGB from Drosophila. These are class II phosphatidylinositol transfer proteins (PITPs) which can transfer phosphatidylinositol (PI) between membranes [1]. RDGB can also transfer phosphatidic acid (PA) between membranes [2]. PTIM1/2 bind PI, phosphatidylcholine (PC) and (PA) with the binding affinity order of PI > PA > PC [2].	Domain
A, B, C	PF24694	PITM 1-3, LNS2 domain (LNS2_PITM1-3)	PITM 1-3, LNS2 domain	This entry represents the LNS2 domain found at the C-terminal of Membrane-associated phosphatidylinositol transfer protein 1-3 (PITM1-3, class II PITPs) and RDGB from Drosophila [1]. This domain, in contrast to lipins where it was first described, in ...	This entry represents the LNS2 domain found at the C-terminal of Membrane-associated phosphatidylinositol transfer protein 1-3 (PITM1-3, class II PITPs) and RDGB from Drosophila [1]. This domain, in contrast to lipins where it was first described, in class II PITPs can bind phosphatidic acid (PA) but not hydrolyse it [1]. RDGB is required to regulate phosphoinositide turnover during G-protein activated phospholipase C signalling [1]. PITM 1-3 catalyse the transfer of phosphatidylinositol (PI) between membranes [1,2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Membrane-associated phosphatidylinositol transfer protein 1	binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding calcium ion binding metal ion binding small molecule binding anion binding phosphatidic acid binding phosphatidylcholine transporter activity lipid transporter activity transporter activity binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding calcium ion binding metal ion binding small molecule binding anion binding phosphatidic acid binding phosphatidylcholine transporter activity lipid transporter activity transporter activity phospholipid transporter activity protein tyrosine kinase binding protein binding kinase binding signaling receptor binding receptor tyrosine kinase binding enzyme binding protein kinase binding phosphatidylcholine binding quaternary ammonium group binding phospholipid transfer activity lipid transfer activity phosphatidylinositol transfer activity	localization establishment of protein localization protein transport transport macromolecule localization intracellular protein localization establishment of localization phospholipid transport lipid localization lipid transport organophosphate ester transport	midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system midbody cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment membrane Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle Golgi stack organelle membrane cell division site cell periphery cleavage furrow plasma membrane plasma membrane region endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane lipid droplet membraneless organelle intracellular membraneless organelle cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR031315	LNS2/PITP	Domain
A, B, C	IPR001666	Phosphatidylinositol transfer protein	Family
A, B, C	IPR023393	START-like domain superfamily	Homologous Superfamily
A, B, C	IPR055261	Phosphatidylinositol transfer protein, N-terminal	Domain
A, B, C	IPR023214	HAD superfamily	Homologous Superfamily
A, B, C	IPR004177	DDHD domain	Domain
A, B, C	IPR036412	HAD-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.