9L62 | pdb_00009l62

A novel allosteric covalent inhibitory site of fucosyltransferase 8 revealed by crystal structures

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF14604	Variant SH3 domain (SH3_9)	Variant SH3 domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-(1,6)-fucosyltransferase	fucosyltransferase activity glycosyltransferase activity transferase activity hexosyltransferase activity catalytic activity alpha-(1->6)-fucosyltransferase activity glycoprotein 6-alpha-L-fucosyltransferase activity catalytic activity, acting on a protein catalytic activity, acting on a glycoprotein SH3 domain binding protein binding binding protein domain specific binding	monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process fucose metabolic process L-fucose metabolic process fucose catabolic process L-fucose catabolic process small molecule metabolic process metabolic process cellular process monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process fucose metabolic process L-fucose metabolic process fucose catabolic process L-fucose catabolic process small molecule metabolic process metabolic process cellular process monosaccharide catabolic process small molecule catabolic process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process multicellular organismal process respiratory gaseous exchange by respiratory system cellular response to stimulus integrin-mediated signaling pathway cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process N-glycan processing glycoprotein metabolic process protein N-linked glycosylation protein metabolic process cellular response to oxidative stress regulation of cellular response to stress cellular response to chemical stress regulation of cellular response to oxidative stress response to oxidative stress cellular response to chemical stimulus cellular response to stress regulation of response to stimulus response to stress regulation of response to stress response to chemical regulation of response to oxidative stress ameboidal-type cell migration cell migration fibroblast migration cell motility viral gene expression viral protein processing viral process developmental process multicellular organism development embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development receptor metabolic process nucleoside phosphate metabolic process nucleotide-sugar metabolic process GDP-L-fucose metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process phosphorus metabolic process oligosaccharide biosynthetic process carbohydrate biosynthetic process oligosaccharide metabolic process cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure Golgi cisterna membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle Golgi stack cytoplasm organelle membrane Golgi membrane bounding membrane of organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR027350	Glycosyltransferase family 23 (GT23) domain	Domain
A, B	IPR035653	Alpha-(1,6)-fucosyltransferase, SH3 domain	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR015827	Alpha-(1,6)-fucosyltransferase	Family
A, B	IPR045573	Alpha-(1,6)-fucosyltransferase, N- and catalytic domain	Domain
A, B	IPR001452	SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BYC5	subependymal giant cell astrocytoma Barrett esophagus Crohn disease invasive ductal breast carcinoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma schizophrenia tuberculosis congenital disorder of glycosylation cystic fibrosis large cell medulloblastoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma Barrett esophagus Crohn disease invasive ductal breast carcinoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma schizophrenia tuberculosis congenital disorder of glycosylation cystic fibrosis large cell medulloblastoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Schizophrenia and related disorders ulcerative colitis congenital disorder of glycosylation with defective fucosylation esophageal adenocarcinoma lung adenocarcinoma medulloblastoma ovarian cancer periodontitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.