9LVQ | pdb_00009lvq

Room temperature structure of the human heart fatty acid-binding protein complexed with octanoic acid

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Fatty acid-binding protein, heart	fatty acid binding organic acid binding binding ion binding anion binding long-chain fatty acid binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding cytoskeletal protein binding protein binding icosatetraenoic acid binding long-chain fatty acid transmembrane transporter activity fatty acid binding organic acid binding binding ion binding anion binding long-chain fatty acid binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding cytoskeletal protein binding protein binding icosatetraenoic acid binding long-chain fatty acid transmembrane transporter activity lipid transporter activity lipid transmembrane transporter activity fatty acid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity transmembrane transporter activity oleic acid binding	response to stimulus response to chemical response to xenobiotic stimulus cellular localization intracellular lipid transport transport lipid localization lipid transport intracellular transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process response to stimulus response to chemical response to xenobiotic stimulus cellular localization intracellular lipid transport transport lipid localization lipid transport intracellular transport establishment of localization localization macromolecule localization establishment of localization in cell cellular process phospholipid homeostasis chemical homeostasis homeostatic process lipid homeostasis organic anion transport carboxylic acid transport organic acid transport monocarboxylic acid transport fatty acid transport long-chain fatty acid transport sterol homeostasis cholesterol homeostasis fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process metabolic process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process lipid metabolic process regulation of cellular process regulation of lipid metabolic process positive regulation of biological process lipid biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process phospholipid metabolic process positive regulation of metabolic process positive regulation of biosynthetic process phosphate-containing compound metabolic process positive regulation of lipid metabolic process phosphorus metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process positive regulation of phosphorus metabolic process biological regulation positive regulation of phospholipid biosynthetic process regulation of phospholipid metabolic process phospholipid biosynthetic process regulation of phospholipid biosynthetic process positive regulation of phospholipid metabolic process biosynthetic process positive regulation of lipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process regulation of phosphorus metabolic process regulation of lipid biosynthetic process regulation of metabolic process glycerophospholipid metabolic process phosphatidylcholine metabolic process glycerophospholipid biosynthetic process regulation of phosphatidylcholine metabolic process glycerolipid biosynthetic process glycerolipid metabolic process phosphatidylcholine biosynthetic process regulation of phosphatidylcholine biosynthetic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process response to hormone response to endogenous stimulus response to peptide hormone response to insulin response to oxygen-containing compound response to nitrogen compound developmental process fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation regulation of localization import into cell regulation of lipid transport lipid import into cell long-chain fatty acid import into cell regulation of transport regulation of long-chain fatty acid import into cell positive regulation of lipid localization regulation of fatty acid transport positive regulation of organic acid transport positive regulation of lipid transport positive regulation of transport regulation of lipid localization positive regulation of long-chain fatty acid import into cell regulation of organic acid transport positive regulation of fatty acid transport ketone metabolic process regulation of fatty acid oxidation fatty acid oxidation regulation of small molecule metabolic process lipid oxidation lipid modification regulation of ketone metabolic process regulation of fatty acid metabolic process response to lipid response to fatty acid	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol sarcoplasm extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol sarcoplasm intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR012674	Calycin	Homologous Superfamily
A	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain
A	IPR000463	Cytosolic fatty-acid binding	Domain
A	IPR031259	Intracellular lipid binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P05413	myopathy Necrosis oligodendroglioma pilocytic astrocytoma psoriasis astrocytic tumor dermatomyositis juvenile dermatomyositis lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer schizophrenia atypical teratoid rhabdoid tumor myopathy Necrosis oligodendroglioma pilocytic astrocytoma psoriasis astrocytic tumor dermatomyositis juvenile dermatomyositis lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer schizophrenia atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma lung carcinoma malignant mesothelioma muscle tissue disease Pick disease primitive neuroectodermal tumor ulcerative colitis Crohn disease glioblastoma limb-girdle muscular dystrophy malignant ependymoma MALT lymphoma muscular disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.