9RFB | pdb_00009rfb

Crystal Structure of Human Rac1 in Complex with the Scaffold Protein POSH (residues 321-348)

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	E3 ubiquitin-protein ligase SH3RF1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity cation binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity MAP-kinase scaffold activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death protein autoubiquitination regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death protein autoubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of protein metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication positive regulation of signaling multicellular organismal process regulation of leukocyte differentiation cellular developmental process regulation of developmental process regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation cell development regulation of CD4-positive, alpha-beta T cell differentiation mononuclear cell differentiation regulation of alpha-beta T cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation CD4-positive, alpha-beta T cell differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development alpha-beta T cell differentiation T cell activation CD4-positive, alpha-beta T cell activation cell differentiation anatomical structure development alpha-beta T cell activation regulation of immune system process regulation of multicellular organismal process T cell differentiation developmental process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of hemopoiesis regulation of lymphocyte activation leukocyte differentiation response to aldosterone response to ketone response to lipid response to endogenous stimulus response to alcohol response to oxygen-containing compound response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to chemical negative regulation of signaling extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway neuron migration nervous system development generation of neurons neurogenesis cell migration cell motility system development CD8-positive, alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation leukocyte proliferation regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of CD8-positive, alpha-beta T cell proliferation cell population proliferation regulation of T cell proliferation mononuclear cell proliferation regulation of cell population proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm
A, B	Ras-related C3 botulinum toxin substrate 1	thioesterase binding protein binding binding enzyme binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP-dependent protein binding guanyl nucleotide binding thioesterase binding protein binding binding enzyme binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP-dependent protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding kinase binding protein kinase binding Rho GDP-dissociation inhibitor binding GDP-dissociation inhibitor binding G protein activity molecular function regulator activity	regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of immune system process cell motility regulation of neutrophil migration locomotion olfactory bulb interneuron differentiation multicellular organismal process cellular developmental process forebrain development central nervous system neuron development cell development substrate-independent telencephalic tangential migration central nervous system neuron differentiation multicellular organism development neurogenesis neuron differentiation telencephalon cell migration forebrain cell migration cell differentiation substrate-independent telencephalic tangential interneuron migration anatomical structure development olfactory bulb development system development developmental process head development embryonic olfactory bulb interneuron precursor migration forebrain generation of neurons olfactory lobe development animal organ development brain development nervous system development tangential migration from the subventricular zone to the olfactory bulb generation of neurons forebrain neuron development central nervous system development olfactory bulb interneuron development neuron development telencephalon development forebrain neuron differentiation cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of signaling cell surface receptor signaling pathway response to stimulus signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT regulation of cell communication signal transduction regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular component organization or biogenesis cell projection assembly regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion positive regulation of cellular process regulation of cellular component size regulation of biological quality regulation of cell size regulation of anatomical structure size substrate adhesion-dependent cell spreading positive regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading regulation of localization import into cell cellular localization regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cell junction assembly regulation of cell-substrate junction organization focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly response to osmotic stress hyperosmotic response response to stress response to abiotic stimulus heart development heart morphogenesis cell adhesion involved in heart morphogenesis circulatory system development anatomical structure morphogenesis animal organ morphogenesis regulation of cell adhesion involved in heart morphogenesis response to wounding organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization sphingolipid mediated signaling pathway sphingosine-1-phosphate receptor signaling pathway G protein-coupled receptor signaling pathway superoxide metabolic process superoxide anion generation reactive oxygen species metabolic process metabolic process enucleate erythrocyte maturation erythrocyte development homeostatic process erythrocyte maturation enucleate erythrocyte development myeloid cell homeostasis cell maturation erythrocyte homeostasis cellular component disassembly enucleation hemopoiesis erythrocyte enucleation developmental maturation erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation anatomical structure maturation myeloid cell development homeostasis of number of cells enucleate erythrocyte differentiation regulation of cytoskeleton organization regulation of actin filament-based process regulation of organelle organization regulation of actin cytoskeleton organization heart process cellular response to nitrogen compound system process response to angiotensin response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin cellular response to endogenous stimulus circulatory system process response to hormone G protein-coupled receptor signaling pathway involved in heart process angiotensin-activated signaling pathway involved in heart process cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization protein-containing complex assembly positive regulation of cell communication small GTPase-mediated signal transduction positive regulation of signal transduction regulation of small GTPase mediated signal transduction intracellular signal transduction Rho protein signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling neuron migration regulation of neuron migration regulation of hydrogen peroxide metabolic process hydrogen peroxide metabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process cortical cytoskeleton organization regulation of postsynapse assembly regulation of synapse structure or activity synapse organization regulation of synapse assembly postsynapse organization postsynapse assembly regulation of postsynapse organization regulation of synapse organization synapse assembly ruffle organization ruffle assembly ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis embryo development sensory organ morphogenesis inner ear development cochlea development inner ear morphogenesis cochlea morphogenesis embryonic organ development positive regulation of organelle organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of protein polymerization regulation of actin filament polymerization regulation of actin filament organization positive regulation of cytoskeleton organization regulation of actin polymerization or depolymerization positive regulation of supramolecular fiber organization regulation of protein polymerization regulation of actin filament length regulation of supramolecular fiber organization positive regulation of actin filament polymerization interneuron migration anatomical structure arrangement trans-synaptic signaling synaptic transmission, GABAergic cell-cell signaling chemical synaptic transmission synaptic signaling anterograde trans-synaptic signaling respiratory burst defense response inflammatory response localization within membrane bicellular tight junction assembly tight junction organization cell-cell junction assembly cell-cell junction organization regulation of bicellular tight junction assembly apical junction assembly positive regulation of bicellular tight junction assembly tight junction assembly regulation of lamellipodium assembly regulation of lamellipodium organization positive regulation of cell projection organization regulation of cell projection organization regulation of cell projection assembly positive regulation of lamellipodium assembly positive regulation of lamellipodium organization regulation of plasma membrane bounded cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly biological process involved in interspecies interaction between organisms response to lipid response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly stress fiber assembly actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of developmental process regulation of cell differentiation regulation of neuron maturation regulation of cell development regulation of cell maturation neuron maturation regulation of neuron differentiation reproductive process sex differentiation development of primary female sexual characteristics regulation of ovarian follicle development developmental process involved in reproduction positive regulation of developmental process development of primary sexual characteristics reproductive structure development ovarian follicle development gonad development reproductive system development positive regulation of ovarian follicle development female gonad development female sex differentiation regulation of protein localization neuromuscular junction development receptor clustering intracellular protein localization regulation of skeletal muscle acetylcholine-gated channel clustering regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane membrane organization positive regulation of receptor clustering skeletal muscle acetylcholine-gated channel clustering positive regulation of protein localization to membrane protein localization to membrane positive regulation of skeletal muscle acetylcholine-gated channel clustering regulation of cellular localization macromolecule localization positive regulation of protein localization homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis negative regulation of biological process cytokine production negative regulation of cellular process regulation of cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process interleukin-23 production regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of interleukin-23 production negative regulation of interleukin-23 production protein localization to cell periphery protein localization to plasma membrane cerebral cortex cell migration cerebral cortex radially oriented cell migration pallium development cerebral cortex development positive regulation of dendritic spine development regulation of dendritic spine development neuron projection development dendrite development dendritic spine development cell surface receptor protein tyrosine kinase signaling pathway hepatocyte growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of transport negative regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis receptor-mediated endocytosis Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway Wnt signaling pathway Rac protein signal transduction cell chemotaxis chemotaxis taxis regulation of neuronal synaptic plasticity regulation of synaptic plasticity modulation of chemical synaptic transmission regulation of trans-synaptic signaling establishment or maintenance of cell polarity regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization microtubule polymerization or depolymerization positive regulation of microtubule polymerization or depolymerization regulation of microtubule-based process microtubule polymerization positive regulation of microtubule polymerization regulation of microtubule polymerization microtubule-based process regulation of microtubule cytoskeleton organization cerebral cortex GABAergic interneuron differentiation GABAergic neuron differentiation cerebral cortex GABAergic interneuron development cerebral cortex neuron differentiation negative regulation of locomotion regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration ameboidal-type cell migration negative regulation of cell motility negative regulation of cell migration positive regulation of ruffle assembly regulation of ruffle assembly positive regulation of locomotion endothelial cell migration positive regulation of cell migration positive regulation of endothelial cell migration positive regulation of cell motility regulation of endothelial cell migration regulation of MAPK cascade ERK5 cascade regulation of ERK5 cascade MAPK cascade inner ear receptor cell development epidermis development cell morphogenesis epithelial cell differentiation hair cell differentiation auditory receptor cell morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation inner ear auditory receptor cell differentiation tissue development cell morphogenesis involved in neuron differentiation inner ear receptor cell differentiation auditory receptor cell development axonogenesis motor neuron axon guidance plasma membrane bounded cell projection morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance axon development neuron projection guidance epithelial cell development epithelial cell morphogenesis regulation of respiratory burst dendrite morphogenesis positive regulation of chemotaxis positive regulation of neutrophil chemotaxis positive regulation of immune system process regulation of leukocyte chemotaxis positive regulation of leukocyte chemotaxis positive regulation of granulocyte chemotaxis regulation of neutrophil chemotaxis regulation of response to external stimulus neutrophil chemotaxis regulation of granulocyte chemotaxis positive regulation of response to external stimulus positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis granulocyte chemotaxis leukocyte chemotaxis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process regulation of nitric oxide metabolic process regulation of cell shape regulation of cell morphogenesis regulation of anatomical structure morphogenesis establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization carbohydrate homeostasis positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis insulin secretion involved in cellular response to glucose stimulus regulation of hormone secretion regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion regulation of secretion by cell secretion by cell positive regulation of hormone secretion response to monosaccharide response to carbohydrate positive regulation of secretion amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of peptide secretion secretion regulation of peptide transport regulation of establishment of protein localization export from cell cellular response to glucose stimulus regulation of protein transport positive regulation of protein secretion peptide transport response to hexose cellular homeostasis positive regulation of transport protein transport regulation of insulin secretion peptide hormone secretion regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport insulin secretion semaphorin-plexin signaling pathway dopaminergic neuron differentiation midbrain development midbrain dopaminergic neuron differentiation positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation engulfment of apoptotic cell phagocytosis, engulfment membrane invagination phagocytosis apoptotic cell clearance plasma membrane invagination	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle 9+2 non-motile cilium non-motile cilium stereocilium bundle cilium neuron projection kinocilium cluster of actin-based cell projections plasma membrane bounded cell projection cell projection cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle 9+2 non-motile cilium non-motile cilium stereocilium bundle cilium neuron projection kinocilium cluster of actin-based cell projections plasma membrane bounded cell projection cell projection organelle intracellular membraneless organelle pericentriolar material intracellular organelle centrosome microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton phagocytic cup cell periphery plasma membrane membrane anchoring junction cell junction focal adhesion cell-substrate junction ruffle cell leading edge leading edge membrane ruffle membrane plasma membrane region cell projection membrane organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cytoplasmic vesicle intracellular vesicle vesicle cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane secretory granule secretory vesicle secretory granule membrane ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule lamellipodium postsynapse postsynaptic membrane synapse synaptic membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle presynapse presynaptic membrane somatodendritic compartment dendrite dendritic tree glutamatergic synapse Golgi apparatus subcompartment Golgi apparatus trans-Golgi network transport vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane exocytic vesicle pigment granule melanosome cell cortex protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex endosome membrane endosome recycling endosome recycling endosome membrane early endosome early endosome membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR035795	E3 ubiquitin-protein ligase SH3RF1, second SH3 domain	Domain
C, D	IPR050384	Endophilin/SH3RF	Family
C, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
C, D	IPR035816	SH3RF1/SH3RF3, fourth SH3 domain	Domain
C, D	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
C, D	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C, D	IPR001452	SH3 domain	Domain
C, D	IPR001841	Zinc finger, RING-type	Domain
A, B	IPR001806	Small GTPase	Family
A, B	IPR003578	Small GTPase Rho	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR005225	Small GTP-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, D	Pharos: Q7Z6J0	interstitial cystitis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis
A, B	Pharos: P63000	dilated cardiomyopathy melanoma Cardiotoxicity cutaneous melanoma congestive heart failure diabetes mellitus liver disease malignant glioma osteosarcoma plasma cell myeloma urinary bladder cancer heart disease hepatocellular carcinoma medulloblastoma ovarian cancer dilated cardiomyopathy melanoma Cardiotoxicity cutaneous melanoma congestive heart failure diabetes mellitus liver disease malignant glioma osteosarcoma plasma cell myeloma urinary bladder cancer heart disease hepatocellular carcinoma medulloblastoma ovarian cancer Sjogren syndrome depressive disorder dilated cardiomyopathy 1A heart failure intellectual disability lymphoplasmacytic lymphoma microcephaly pancreatic intraductal papillary-mucinous neoplasm intellectual disability, autosomal dominant 48

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.