9U80 | pdb_00009u80

Cryo-EM structure of conivaptan-bound human vasopressin V2 receptor complex with Fab

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C [auth R]	Vasopressin V2 receptor,Soluble cytochrome b562	vasopressin receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity signaling receptor activity transmembrane signaling receptor activity binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding vasopressin receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity signaling receptor activity transmembrane signaling receptor activity binding tetrapyrrole binding heme binding electron transfer activity cation binding transition metal ion binding iron ion binding ion binding metal ion binding small molecule binding	regulation of body fluid levels hemostasis biological regulation regulation of biological quality regulation of tube diameter multicellular organismal process regulation of biological process system process regulation of tube size regulation of system process positive regulation of biological process positive regulation of vasoconstriction circulatory system process regulation of blood circulation regulation of body fluid levels hemostasis biological regulation regulation of biological quality regulation of tube diameter multicellular organismal process regulation of biological process system process regulation of tube size regulation of system process positive regulation of biological process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction blood circulation regulation of anatomical structure size regulation of biosynthetic process regulation of cellular process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular response to stimulus response to stimulus signaling cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to endogenous stimulus response to chemical cellular response to hormone stimulus response to peptide response to cytokine regulation of systemic arterial blood pressure by hormone regulation of systemic arterial blood pressure mediated by a chemical signal regulation of blood pressure regulation of systemic arterial blood pressure endocrine process regulation of systemic arterial blood pressure by vasopressin cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling renal system process regulation of urine volume renal water retention negative regulation of urine volume developmental process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development negative regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process positive regulation of adenylate cyclase activity positive regulation of molecular function regulation of molecular function positive regulation of cyclase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of catalytic activity positive regulation of catalytic activity positive regulation of lyase activity positive regulation of systemic arterial blood pressure positive regulation of blood pressure electron transport chain generation of precursor metabolites and energy	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cell periphery plasma membrane Golgi apparatus endomembrane system endosome perinuclear region of cytoplasm endoplasmic reticulum periplasmic space
B [auth L]	anti-BRIL Fab light chain	-	-	-
A [auth H]	anti-BRIL Fab heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth R]	IPR000161	Vasopressin V2 receptor	Family
C [auth R]	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
C [auth R]	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
C [auth R]	IPR001817	Vasopressin receptor	Family
C [auth R]	IPR010980	Cytochrome c/b562	Homologous Superfamily
C [auth R]	IPR009155	Cytochrome b562	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth R]	Pharos: P30518	nephrogenic diabetes insipidus nephrogenic syndrome of inappropriate antidiuresis congenital adrenal hyperplasia cardiomyopathy congestive heart failure diabetes insipidus, nephrogenic, X-linked Oliguria diabetes insipidus X-linked disease inappropriate ADH syndrome hereditary von Willebrand disease intellectual disability systemic lupus erythematosus kidney disease diabetes insipidus, nephrogenic, autosomal nephrogenic diabetes insipidus nephrogenic syndrome of inappropriate antidiuresis congenital adrenal hyperplasia cardiomyopathy congestive heart failure diabetes insipidus, nephrogenic, X-linked Oliguria diabetes insipidus X-linked disease inappropriate ADH syndrome hereditary von Willebrand disease intellectual disability systemic lupus erythematosus kidney disease diabetes insipidus, nephrogenic, autosomal hemophilia A autosomal dominant hypophosphatemic rickets celiac disease rheumatoid arthritis genetic endocrine growth disease heart failure

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.