The COMMD (Copper Metabolism Murr1 (Mouse U2af1-rs1 region 1) Domain) proteins are highly conserved in metazoans and unicellular protozoa. There are ten family members that play key roles in intracellular trafficking and in the regulation of transcri ...
The COMMD (Copper Metabolism Murr1 (Mouse U2af1-rs1 region 1) Domain) proteins are highly conserved in metazoans and unicellular protozoa. There are ten family members that play key roles in intracellular trafficking and in the regulation of transcription. A hallmark of the COMMD family members is a highly conserved C-terminal sequence of 70-80 amino acids called the COMM domain, which has no known structure. This entry represents the N-terminal domain of these proteins, which is referred to as the HN (helical N-terminal) domain, is more variable in sequence across the ten proteins [1,2]. Therefore, this entry includes COMMD2-7/10, while COMMD1 HN domain is represented in Pfam:PF17221, COMMD9 HN domain in Pfam:PF20923. Human (and the mammalian homologues) COMMD6 lacks the HN domain, however, it is present in COMMD6 from other species, such as Xenopus sp. This helical N-terminal domain has a globular architecture and is composed of a six-helix bundle with a meander topology [1,2].
