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Explore in 3D: Sequence Alignments
1CLQ_3 - Summary | Structure
Name: DNA-directed DNA polymerase
Organism: Escherichia phage RB69
Experimental Method: X-ray
Resolution: 2.7 Å
Molecular Weight: 104.743 kDa

Mu-cyrtautoxin-As1a

UniProtKB accession:  P49268
Grouped By:  Matching UniProtKB accession
Group Content:  
Polymer Entities matching query 120
Go to UniProtKB:  P49268
UniProtKB description:  The recombinant mu-cyrtautoxin-As1a potently and voltage-independently blocks voltage-gated sodium channels (Nav) of insects. It acts by pluging the outer vestibule of the channel. It acts in combination with a weak (30%) voltage-independent block of insect voltage-gated calcium (Cav) channels (low-voltage and high-voltage channels). Tested on DUM neurons, it inhibits sodium currents with an IC(50) of 540 nM (and a Hill coefficient >1, reflecting an incomplete block at higher concentrations). In vivo, it induces flaccid paralysis in adult Australian sheep blowfly Lucilia cuprina (PubMed:23473802). It is both paralytic and lethal, when injected into lepidopteran larvae. It is a slower acting toxin, being lethal at 24 hours, but not paralytic at 1 hour post-injection (PubMed:1440641).
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