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Member 1 of 120
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Explore in 3D: Sequence Alignments
Mu-cyrtautoxin-As1a
UniProtKB accession: P49268
Grouped By: Matching UniProtKB accession
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Polymer Entities matching query 120
Go to UniProtKB: P49268
UniProtKB description: The recombinant mu-cyrtautoxin-As1a potently and voltage-independently blocks voltage-gated sodium channels (Nav) of insects. It acts by pluging the outer vestibule of the channel. It acts in combination with a weak (30%) voltage-independent block of insect voltage-gated calcium (Cav) channels (low-voltage and high-voltage channels). Tested on DUM neurons, it inhibits sodium currents with an IC(50) of 540 nM (and a Hill coefficient >1, reflecting an incomplete block at higher concentrations). In vivo, it induces flaccid paralysis in adult Australian sheep blowfly Lucilia cuprina (PubMed:23473802). It is both paralytic and lethal, when injected into lepidopteran larvae. It is a slower acting toxin, being lethal at 24 hours, but not paralytic at 1 hour post-injection (PubMed:1440641).
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