Eukaryotic initiation factor 4A-I

UniProtKB accession: P60842

Grouped By: Matching UniProtKB accession

Group Content:

Polymer Entities matching query 5

Go to UniProtKB: P60842

UniProtKB description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963). In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (PubMed:20156963).

Group Members:

Release Date:

Structure Features

Sequence Features

Experimental Features

Organisms

Protein Domains

Function