Bifunctional albaflavenone monooxygenase/terpene synthase

UniProtKB accession:  Q9K498

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UniProtKB description:  Involved in the biosynthesis of the sesquiterpenoid antibiotic albaflavenone. Catalyzes the two-step allylic oxidation of epi-isozizaene to albaflavenone. First carries out a non-stereo-specific oxidation of epi-isozizaene to give a mixture of the albaflavenol epimers ((5R)-albaflavenol and (5S)-albaflavenol), each of which can serve as substrate for the second oxidation to yield albaflavenone. This is quite different from most other P450s which catalyze regio- and stereospecific oxidation (PubMed:18234666, PubMed:19858213). In addition, displays a farnesene synthase activity with farnesyl diphosphate (FPP) as substrate (PubMed:19858213).