Download MendeleyFc gamma RIIa 27W/131H variant ectodomain
Foy, E.G., Thomsen, M., Goldman, A., Robinson, J.I.To be published.
8CHA
Fc gamma RIIa 27W/131H variant ectodomain
- PDB DOI: https://doi.org/10.2210/pdb8CHA/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): Yes
- Deposited: 2023-02-07 Released: 2024-05-22
- Funding Organization(s): Other private, Wellcome Trust, European Research Council (ERC), Biotechnology and Biological Sciences Research Council (BBSRC), Academy of Finland, Medical Research Council (MRC, United Kingdom)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.81 Å
- R-Value Free: 0.225
- R-Value Work: 0.193
- R-Value Observed: 0.194
Starting Model: experimental
View more details
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Low affinity immunoglobulin gamma Fc region receptor II-a | 209 | Homo sapiens | Mutation(s): 1 Gene Names: FCGR2A, CD32, FCG2, FCGR2A1, IGFR2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P12318 (Homo sapiens) Explore P12318 Go to UniProtKB: P12318 | |||||
PHAROS: P12318 GTEx: ENSG00000143226 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12318 | ||||
Glycosylation | |||||
| Glycosylation Sites: 1 | Go to GlyGen: P12318-1 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Oligosaccharides
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | B | 4 | N/A | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G81315DD GlyCosmos: G81315DD GlyGen: G81315DD | |||||
Small Molecules
| Ligands 7 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 16P Query on 16P | G [auth A] | 3,6,9,12,15,18-HEXAOXAICOSANE C14 H30 O6 IXFAFGFZFQHRLB-UHFFFAOYSA-N |  | ||
| FLC Query on FLC | C [auth A] | CITRATE ANION C6 H5 O7 KRKNYBCHXYNGOX-UHFFFAOYSA-K |  | ||
| FWN Query on FWN | J [auth A] | 2-[2-(2-ethoxyethoxy)ethoxy]ethanol C8 H18 O4 WFSMVVDJSNMRAR-UHFFFAOYSA-N |  | ||
| PGE Query on PGE | H [auth A] | TRIETHYLENE GLYCOL C6 H14 O4 ZIBGPFATKBEMQZ-UHFFFAOYSA-N |  | ||
| PO4 Query on PO4 | D [auth A], E [auth A], F [auth A] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
| DXE Query on DXE | I [auth A] | 1,2-DIMETHOXYETHANE C4 H10 O2 XTHFKEDIFFGKHM-UHFFFAOYSA-N |  | ||
| NA Query on NA | K [auth A] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.81 Å
- R-Value Free: 0.225
- R-Value Work: 0.193
- R-Value Observed: 0.194
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 49.931 | α = 90 |
| b = 76.526 | β = 90 |
| c = 108.279 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| Coot | model building |
| Aimless | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-05-22 Deposition Author(s): Foy, E.G., Thomsen, M., Goldman, A., Robinson, J.I.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other private | 19764 | |
| Wellcome Trust | United Kingdom | 091322/2/10/2 |
| European Research Council (ERC) | European Union | 708051 |
| Biotechnology and Biological Sciences Research Council (BBSRC) | United Kingdom | ALERT-13 |
| Biotechnology and Biological Sciences Research Council (BBSRC) | United Kingdom | BB/M021610/1 |
| Academy of Finland | Finland | 1252206 |
| Medical Research Council (MRC, United Kingdom) | United Kingdom | MR/K015346/1 |
Revision History (Full details and data files)
- Version 1.0: 2024-05-22
Type: Initial release - Version 1.1: 2024-10-09
Changes: Structure summary
