Download MendeleyCrystal structure of haspin (GSG2) in complex with MU1668
Chaikuad, A., Paruch, K., Knapp, S., Structural Genomics Consortium (SGC)To be published.
9FLC
Crystal structure of haspin (GSG2) in complex with MU1668
- PDB DOI: https://doi.org/10.2210/pdb9FLC/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-06-04 Released: 2024-09-11
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.18 Å
- R-Value Free: 0.197
- R-Value Work: 0.165
- R-Value Observed: 0.166
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Serine/threonine-protein kinase haspin | 357 | Homo sapiens | Mutation(s): 0 Gene Names: HASPIN, GSG2 EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8TF76 (Homo sapiens) Explore Q8TF76 Go to UniProtKB: Q8TF76 | |||||
PHAROS: Q8TF76 GTEx: ENSG00000177602 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8TF76 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| A1IDA (Subject of Investigation/LOI) Query on A1IDA | B [auth A] | 5-(1-methylpyrazol-3-yl)-3-pyridin-4-yl-thieno[3,2-b]pyridine C16 H12 N4 S LXGOVQVQBLFWHN-UHFFFAOYSA-N |  | ||
| MPD Query on MPD | C [auth A] | (4S)-2-METHYL-2,4-PENTANEDIOL C6 H14 O2 SVTBMSDMJJWYQN-YFKPBYRVSA-N |  | ||
| GOL Query on GOL | D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.18 Å
- R-Value Free: 0.197
- R-Value Work: 0.165
- R-Value Observed: 0.166
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 77.822 | α = 90 |
| b = 77.908 | β = 90 |
| c = 81.313 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| Aimless | data scaling |
| XDS | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-09-11 Deposition Author(s): Chaikuad, A., Paruch, K., Knapp, S., Structural Genomics Consortium (SGC)
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2024-09-11
Type: Initial release
