Download MendeleyConformational flexibility in HLA-B8: peptide tuning structural and dynamical changes
Li, L., Peng, X., Vinjamuri, S., Bouvier, M.To be published.
9MEF | pdb_00009mef
Conformational flexibility in HLA-B8: peptide tuning structural and dynamical changes
- PDB DOI: https://doi.org/10.2210/pdb9MEF/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, Human immunodeficiency virus 1
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2024-12-06 Released: 2025-12-10
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.27 Å
- R-Value Free: 0.227 (Depositor), 0.237 (DCC)
- R-Value Work: 0.197 (Depositor), 0.206 (DCC)
- R-Value Observed: 0.198 (Depositor)
Starting Model: in silico
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| MHC class I protein | 275 | Homo sapiens | Mutation(s): 1 Gene Names: HLA-B |  | |
UniProt | |||||
Find proteins for A0A3G6II09 (Homo sapiens) Explore A0A3G6II09 Go to UniProtKB: A0A3G6II09 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A3G6II09 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Beta-2-microglobulin | 100 | Homo sapiens | Mutation(s): 0 Gene Names: B2M, CDABP0092, HDCMA22P |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61769 (Homo sapiens) Explore P61769 Go to UniProtKB: P61769 | |||||
PHAROS: P61769 GTEx: ENSG00000166710 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61769 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| ARG-ALA-ARG-ALA-ARG-ALA-ARG-ALA-ARG-ALA-ARG-ALA-PHE-PRO-LYS-LYS-LYS-TYR-CYS-LEU | 20 | Human immunodeficiency virus 1 | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.27 Å
- R-Value Free: 0.227 (Depositor), 0.237 (DCC)
- R-Value Work: 0.197 (Depositor), 0.206 (DCC)
- R-Value Observed: 0.198 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 50.75 | α = 90 |
| b = 81.304 | β = 90 |
| c = 110.504 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| PHASER | phasing |
| XDS | data scaling |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-12-10 Deposition Author(s): Li, L., Bouvier, M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | R01 AI114467 |
Revision History (Full details and data files)
- Version 1.0: 2025-12-10
Type: Initial release
