Download MendeleyPfs230 domain 1 bound by RUPA-32 Fab
Ivanochko, D., Julien, J.P.To be published.
9N8I | pdb_00009n8i
Pfs230 domain 1 bound by RUPA-39 Fab
- PDB DOI: https://doi.org/10.2210/pdb9N8I/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, Plasmodium falciparum 3D7, Lama glama
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2025-02-08 Released: 2026-02-04
- Funding Organization(s): Bill & Melinda Gates Foundation, National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID), Canadian Institutes of Health Research (CIHR)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.233 (Depositor), 0.234 (DCC)
- R-Value Work: 0.188 (Depositor), 0.189 (DCC)
- R-Value Observed: 0.190 (Depositor)
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| RUPA-39 Heavy chain | 227 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| RUPA-39 Kappa chain | 215 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Gametocyte surface protein P230 | C [auth E] | 181 | Plasmodium falciparum 3D7 | Mutation(s): 0 Gene Names: PFS230, PF230, S230, PF3D7_0209000 |  |
UniProt | |||||
Find proteins for P68874 (Plasmodium falciparum (isolate 3D7)) Explore P68874 Go to UniProtKB: P68874 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P68874 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Anti-kappa nanobody | D [auth F] | 122 | Lama glama | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| EDO Query on EDO | E [auth A] G [auth B] H [auth B] I [auth B] J [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
| CA Query on CA | F [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 Å
- R-Value Free: 0.233 (Depositor), 0.234 (DCC)
- R-Value Work: 0.188 (Depositor), 0.189 (DCC)
- R-Value Observed: 0.190 (Depositor)
Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 62.95 | α = 90 |
| b = 76.11 | β = 96.34 |
| c = 88.64 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XDS | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2026-02-04 Deposition Author(s): Ivanochko, D., Semesi, A., Julien, J.P.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Bill & Melinda Gates Foundation | United States | INV-008866 and OPP1156262 |
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | 1R01AI148557-01A1 |
| Canadian Institutes of Health Research (CIHR) | Canada | 428410 |
Revision History (Full details and data files)
- Version 1.0: 2026-02-04
Type: Initial release
