9Z3Q | pdb_00009z3q

Cryo-EM structure of KSHV glycoprotein gHgL in complex with MLKH3 and MLKH10 FABs

Experimental Data Snapshot

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.51 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 

Starting Models: in silico, experimental
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wwPDB Validation   3D Report Full Report


This is version 1.0 of the entry. See complete history. 


Literature

Monoclonal neutralizing antibodies elicited by infection with Kaposi sarcoma-associated herpesvirus reveal critical sites of vulnerability on gH/gL.

Wan, Y.H., Pernikoff, S., Aldridge, N., Lang, K., Dudley, H., Scharffenberger, S., Kher, G., Phipps, W.T., Pancera, M., Boonyaratanakornkit, J., McGuire, A.T.

To be published.

Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
MLKH10 Light chain FV112Mus musculusMutation(s): 0 
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
MLKH10 Heavy chain FV121Mus musculusMutation(s): 0 
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
MLKH3 Light chain FV107Mus musculusMutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
MLKH3 Heavy chain FV122Mus musculusMutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
Envelope glycoprotein H728Human gammaherpesvirus 8Mutation(s): 0 
Gene Names: gH, ORF22
UniProt
Find proteins for F5HAK9 (Human herpesvirus 8 type P (isolate GK18))
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Go to UniProtKB:  F5HAK9
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UniProt GroupF5HAK9
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
Envelope glycoprotein L176Human gammaherpesvirus 8Mutation(s): 0 
Gene Names: gL, 47
UniProt
Find proteins for F5HDB7 (Human herpesvirus 8 type P (isolate GK18))
Explore F5HDB7 
Go to UniProtKB:  F5HDB7
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UniProt GroupF5HDB7
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: ELECTRON MICROSCOPY
  • Resolution: 3.51 Å
  • Aggregation State: PARTICLE 
  • Reconstruction Method: SINGLE PARTICLE 
EM Software:
TaskSoftware PackageVersion
RECONSTRUCTIONcryoSPARC4.7.1
MODEL REFINEMENTPHENIX2.0_5793

Structure Validation

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Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
National Institutes of Health/National Cancer Institute (NIH/NCI)United StatesU01CA295050

Revision History  (Full details and data files)

  • Version 1.0: 2025-12-10
    Type: Initial release