Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyChaperone J-domain 8036316 3000721 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProtein kinase-like (PK-like) 8069143 3000066 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8069143 3000066 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyChaperone J-domain 8036316 3000721 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BDnaJe4wb7B1 A: alpha bundlesX: Chaperone J-domain (From Topology)H: Chaperone J-domain (From Topology)T: Chaperone J-domainF: DnaJECOD (1.6)
BPkinase_Tyre4wb7B2 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
ADnaJe4wb7A2 A: alpha bundlesX: Chaperone J-domain (From Topology)H: Chaperone J-domain (From Topology)T: Chaperone J-domainF: DnaJECOD (1.6)
APkinase_Tyre4wb7A1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B1.10.287.110 Mainly Alpha Orthogonal Bundle Helix Hairpins DnaJ domainCATH (4.3.0)
B3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
B1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)
A1.10.287.110 Mainly Alpha Orthogonal Bundle Helix Hairpins DnaJ domainCATH (4.3.0)
A3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
A1.10.510.10 Mainly Alpha Orthogonal Bundle Transferase(Phosphotransferase) domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00226DnaJ domain (DnaJ)DnaJ domainDnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are conf ...DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature [2].
Domain
A, B
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha
C [auth I],
D [auth J]
PKI (5-24)

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosP25685
C [auth I],
D [auth J]
PharosP61925

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
SEP Parent Component: SER

RESIDAA0037

PSI-MOD :  O-phospho-L-serine MOD:00046
A, B
TPO Parent Component: THR

RESIDAA0037 , AA0038

PSI-MOD :  O-phospho-L-serine MOD:00046 , O-phospho-L-threonine MOD:00047