Download MendeleyMolecular Basis of c-MET Inhibition by Approved Small Molecule Drugs: A Structural Perspective
Russell, I.C., Bachurska-Szpala, P., van Beek, L., Michaelides, I.N., Phillips, C., Snijder, A., Stubbs, C.J., Collie, G.W.(2026) ACS Med Chem Lett
9T6K | pdb_00009t6k
Crystal structure of wild-type c-MET bound by glumetinib.
- PDB DOI: https://doi.org/10.2210/pdb9T6K/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2025-11-07 Released: 2026-02-18
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.13 Å
- R-Value Free: 0.197 (Depositor), 0.188 (DCC)
- R-Value Work: 0.182 (Depositor), 0.174 (DCC)
- R-Value Observed: 0.183 (Depositor)
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hepatocyte growth factor receptor | 296 | Homo sapiens | Mutation(s): 0 Gene Names: MET EC: 2.7.10.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P08581 (Homo sapiens) Explore P08581 Go to UniProtKB: P08581 | |||||
PHAROS: P08581 GTEx: ENSG00000105976 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P08581 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 15P Query on 15P | C [auth A], E [auth A] | POLYETHYLENE GLYCOL (N=34) C69 H140 O35 VUYXVWGKCKTUMF-UHFFFAOYSA-N |  | ||
| A1JT6 (Subject of Investigation/LOI) Query on A1JT6 | B [auth A] | Glumetinib C21 H17 N9 O2 S RYBLECYFLJXEJX-UHFFFAOYSA-N |  | ||
| PEG Query on PEG | D [auth A] | DI(HYDROXYETHYL)ETHER C4 H10 O3 MTHSVFCYNBDYFN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.13 Å
- R-Value Free: 0.197 (Depositor), 0.188 (DCC)
- R-Value Work: 0.182 (Depositor), 0.174 (DCC)
- R-Value Observed: 0.183 (Depositor)
Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 37.958 | α = 90 |
| b = 42.719 | β = 92.5 |
| c = 85.287 | γ = 90 |
| Software Name | Purpose |
|---|---|
| BUSTER | refinement |
| autoPROC | data reduction |
| autoPROC | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2026-02-18 Deposition Author(s): Collie, G.W., van Beek, L.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Not funded | -- |
Revision History (Full details and data files)
- Version 1.0: 2026-02-18
Type: Initial release
