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Structure of the endothelial monocyte activating polypeptide II (EMAP II) in solution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8041934	3000135	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01588	Putative tRNA binding domain (tRNA_bind)	Putative tRNA binding domain	This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypepti ...	This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases [2]. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme [2]. This domain may perform a common function in tRNA aminoacylation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity RNA binding tRNA binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity RNA binding tRNA binding nucleic acid binding enzyme binding GTPase binding	developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis multicellular organism development tube morphogenesis anatomical structure formation involved in morphogenesis anatomical structure development blood vessel development system development leukocyte migration immune system process cell migration cellular process cell motility apoptotic process cell death programmed cell death response to stimulus defense response response to stress inflammatory response regulation of biological process signaling biological regulation cell-cell signaling cell communication positive regulation of cell communication regulation of localization nitrogen compound transport regulation of hormone secretion regulation of cellular process regulation of peptide secretion transport glucagon secretion positive regulation of biological process positive regulation of secretion by cell hormone secretion peptide secretion localization secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion regulation of glucagon secretion amide transport signal release regulation of biological quality regulation of peptide hormone secretion positive regulation of cellular process positive regulation of peptide secretion regulation of signaling positive regulation of glucagon secretion secretion regulation of transport regulation of hormone levels positive regulation of peptide hormone secretion regulation of peptide transport export from cell establishment of localization regulation of secretion peptide transport positive regulation of transport peptide hormone secretion hormone transport regulation of cell communication positive regulation of signaling biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to external biotic stimulus response to virus negative regulation of cell population proliferation cell population proliferation endothelial cell proliferation negative regulation of biological process negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation negative regulation of cellular process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation biosynthetic process metabolic process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex aminoacyl-tRNA synthetase multienzyme complex intracellular protein-containing complex cell surface cytosol extracellular region extracellular space nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002547	tRNA-binding domain	Domain
A	IPR051270	Tyrosine-tRNA ligase and regulatory protein	Family
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q12904	hypomyelinating leukodystrophy 3 leukodystrophy arthrogryposis glioblastoma intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Spastic Paraplegia, Hereditary breast cancer hereditary spastic paraplegia large cell medulloblastoma ovarian cancer plasma cell myeloma tuberculosis pancreatic intraductal papillary-mucinous neoplasm hypomyelinating leukodystrophy 3 leukodystrophy arthrogryposis glioblastoma intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Spastic Paraplegia, Hereditary breast cancer hereditary spastic paraplegia large cell medulloblastoma ovarian cancer plasma cell myeloma tuberculosis pancreatic intraductal papillary-mucinous neoplasm progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.